Oxidative and nitrosative stress in human placenta in Preeclampsia
نویسندگان
چکیده
منابع مشابه
Neuro-oxidative-nitrosative stress in sepsis.
Neuro-oxidative-nitrosative stress may prove the molecular basis underlying brain dysfunction in sepsis. In the current review, we describe how sepsis-induced reactive oxygen and nitrogen species (ROS/RNS) trigger lipid peroxidation chain reactions throughout the cerebrovasculature and surrounding brain parenchyma, due to failure of the local antioxidant systems. ROS/RNS cause structural membra...
متن کاملOxidative Stress and Preeclampsia
Eclampsia is one of the most common pregnancy complications causing high mortality and morbidity for both mother and foetus. Low birth weight and pre-maturity are very common features. Pre-eclampsia is associated with oxidative stress in the maternal circulation. The etiology and pathogenesis of the pregnancy syndrome preeclampsia remain poorly understood. There is substantial evidence to sugge...
متن کاملOxidative stress biomarkers and ADAMTS-12 levels in early- onset severe preeclampsia and placenta previa
Objective Preeclampsia is a unique pregnancy disease characterized by de-novo hypertension and proteinuria after the 20th weeks of gestation. The cause of the disease is still unclear. It is accepted that early-onset (<34th week) preeclampsia is primarily associated with poor, defective placentation due to failure of trophoblastic invasion, whereas late-onset preeclampsia (≥34 weeks) possibly d...
متن کاملOxidative Stress in Placenta: Health and Diseases
During pregnancy, development of the placenta is interrelated with the oxygen concentration. Embryo development takes place in a low oxygen environment until the beginning of the second trimester when large amounts of oxygen are conveyed to meet the growth requirements. High metabolism and oxidative stress are common in the placenta. Reactive oxidative species sometimes harm placental developme...
متن کاملPain-reducing anesthesia prevents oxidative stress in human term placenta.
Anesthesia is sometimes used for the reduction of maternal pain in normal human term labor, but whether the drugs affect oxidative stress remains unclear. The placenta serves as an interface between the maternal and fetal vasculature. In this study, we immunohistochemically analyzed two markers for oxidative stress, namely 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal-modified pr...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.701.2